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eBook MIF: Most Interesting Factor epub

by Richard Bucala

eBook MIF: Most Interesting Factor epub
  • ISBN: 9812706488
  • Author: Richard Bucala
  • Genre: Other
  • Subcategory: Medicine & Health Sciences
  • Language: English
  • Publisher: World Scientific Pub Co Inc; 1 edition (October 15, 2007)
  • Pages: 317 pages
  • ePUB size: 1106 kb
  • FB2 size 1416 kb
  • Formats lit mobi mbr lrf

MIF: Most Interesting Factor.

MIF: Most Interesting Factor.

Find all the books, read about the author, and more. Are you an author? Learn about Author Central. ISBN-13: 978-9812706485.

Mif: A Most Interesting Factor Hardcover – 31 July 2007.

Mif: A Most Interesting Factor by Bucala Richard and Publisher World Scientific. Mif: A Most Interesting Factor. Publisher: World Scientific. Save up to 80% by choosing the eTextbook option for ISBN: 9789812775917, 9812775919. The print version of this textbook is ISBN: 9789812706485, 9812706488. Print ISBN: 9789812706485, 9812706488.

MIF : most interesting factor /. Authors: Bucala, Richard Macrophage Factors %immunology. Authors: Bucala, Richard. Macrophage Factors %physiology. Macrophage Factors %genetics. Macrophage Factors %immunology. Book · January 2007 with 18 Reads. How we measure 'reads'. Orthologs of macrophage migration inhibitory factor (MIF) have been identified in dozens of protozoan and nematode parasites, and the properties of many of these have been investigated and reported upon. Crystallographic analyses have revealed close structural similarity of these with human MIF, and many of these parasite MIFs are able to bind directly to the human MIF receptor CD74. Learn More at LibraryThing. Richard Bucala at LibraryThing. ISBN 9789812706485 (978-981-270-648-5) Hardcover, World Scientific Pub Co Inc, 2007.

Richard Bucala, Richard Bucala. Although first described as a soluble activity produced by activated T cells nearly four decades ago, interest in macrophage migration inhibitory factor (MIF) was rekindled when the mouse homolog of this protein was identified to be secreted from the anterior pituitary gland in a hormone-like fashion (Bernhagen et aL, 1993). MIF was shown to play a critical role in the host inflammatory response to endotoxin

MIF: Most Interesting Factor. T1 - Inflammatory arthritis. AU - Morand, Eric Francis. AU - Leech, Michelle Theresa.

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.
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